Number of Antigens: 49
Gene: RHD and RHCE
Transfusion Reaction: Yes—typically delayed hemolytic transfusion reactions
Anti-D, anti-C, anti-e, and anti-c can cause severe hemolytic transfusion reactions. Hemolysis is typically extravascular
Hemolytic Disease of the Newborn: Yes—the most common cause of HDN.
The D antigen accounts for 50% of maternal alloimmunization. Anti-D and anti-c can cause severe disease. Anti-C, anti-E, and anti-e can cause mild to moderate disease.