Lutheran Blood Group
Number of Antigens: 19
Transfusion Reaction: Yes
Hemolytic Disease of the Newborn: Yes
Lutheran antigens belong to a blood group where two main alleles, Lua and Lub make the current phenotypes Lu(a-b+), Lu (a+b-), and Lu (a+b+). A null phenotype Lu(a-b-) also exists which lacks all Lu antigens, including Lua and Lub (3) It is unknown if it is possible to have antibodies to both Lua and Lub or if a an additional Lutheran antibody that will react with both Lua and Lub will be discovered like in the Kidd blood group.
Note: anti-Lu 3, 4, 5, 6, 8, and 11 have been found (17). Anti-Lu11 does not react with cells that are Lu(a-b-) (16).