Anti-Ku (KEL5)

Blood Group: Kell

Common: Very rare

Causes HDN: Yes 

Anti-Ku can cause severe HDN requiring IUTs. Recombinant erythropoietin (Epogen) has been used successfully on infants affected by anti-Ku [2].

"The Kell system has a rare null phenotype, Ko, in which RBCs lack all Kell antigens. Individuals with this phenotype are healthy but produce anti-Ku when they encounter RBCs that do express Kell antigens. Anti-Ku is capable of causing a mild to severe transfusion reaction with at least one fatal case being reported (5). Therefore, if Ko individuals ever require a blood transfusion, they should only be transfused with Ko blood products." [1]

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