Common: >99.9% of Caucasians and Blacks and >90% of Asians are Dia- and at risk for developing anti-Dia.
Causes HDN: Yes
Critical Titer: 1:16
Anti-Dia can cause moderate to severe HDN [1, 8]. HDN due to Diego antibodies is more common in SE Asia and S. America, though cases have been reported in Japan, China, and Poland.  Anti-Dia has been known to cause problems with jaundice requiring exchange transfusion [3, 5, 8]. If not treated promptly, despite single phototherapy, anti-Dia can cause Kernicterus .
Anti-Dia has been known to be undetectable on maternal indirect coombs test during pregnancy, yet still cause issues with the infant after birth. [2, 5]. Anti-Dia has also been known to cause late onset anemia, such as in this 3 week old infant .