Blood Group: Rh

Common: 20% of caucasians, 4% of blacks, and 53% of asians are at risk for developing anti-C

Causes HDN: Yes
Critical Titer: 1:16

Anti-C can cause severe HDN [1]. One of the most important things to note is that with anti-C the direct coombs test done on baby can come back negative, but baby still be severely (or fatally) affected [2]. Because anti-C can require IUTs and cause fetal death, monitoring for anti-C needs to proceed as aggressively as with anti-D [3]. IVIG can be used to treat jaundice due to anti-C [4].

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