MNS Blood Group
Number of Antigens: 43
Gene: GYPA and GYPB
Transfusion Reaction: Uncommon but potentially severe
Anti-S and anti-s are among the MNS antibodies implicated in causing transfusion reactions.
Hemolytic Disease of the Newborn: Uncommon but potentially severe
Anti-S is more common that anti-s, but both are capable of causing severe-to-fatal HDN.
The MNS antigens are also expressed in the kidney and epithelium.
"Of the MNS antibodies, anti-S is more common than anti-s, and both are capable of causing severe hemolysis.
Less common causes of HDN include anti-M, anti-N, anti-U, anti-Mia, anti-Mta, and anti-Ena (1, 10-15). Other MNS antibodies implicated in HDN are anti-Vw, anti-Mur, anti-Hut, anti-Hil, anti-Mv, anti-Far, anti-sD, anti-Or, and anti-MUT. In addition, other antibodies to low-incidence MNS antigens should be considered as potentially harmful (1, 16-20)."