MNS Blood Group

Number of Antigens: 43

Gene: GYPA and GYPB
Transfusion Reaction:  Uncommon but potentially severe
Anti-S and anti-s are among the MNS antibodies implicated in causing transfusion reactions.

Hemolytic Disease of the Newborn: Uncommon but potentially severe
Anti-S is more common that anti-s, but both are capable of causing severe-to-fatal HDN. 


The MNS antigens are also expressed in the kidney and epithelium. 


Antibodies:

anti-M

anti-N

anti-S

anti-s

anti-U

anti-Mia

anti-Mta

anti-Ena

anti-Vw

anti-Mur

anti-Hut

anti-Hil

anti-Mv

anti-Far

anti-sD

anti-Or

anti-MUT


"Of the MNS antibodies, anti-S is more common than anti-s, and both are capable of causing severe hemolysis.

Less common causes of HDN include anti-M, anti-N, anti-U, anti-Mia, anti-Mta, and anti-Ena (1, 10-15). Other MNS antibodies implicated in HDN are anti-Vw, anti-Mur, anti-Hut, anti-Hil, anti-Mv, anti-Far, anti-sD, anti-Or, and anti-MUT. In addition, other antibodies to low-incidence MNS antigens should be considered as potentially harmful (1, 16-20)."


Reference:

https://www.ncbi.nlm.nih.gov/books/NBK2274/