Lutheran Blood Group

Number of Antigens: 19

Gene:
Transfusion Reaction: Yes
Hemolytic Disease of the Newborn: Yes

Antibodies:

LuA (aka Lu1)

LuB (aka Lu2)


Lutheran antigens belong to a blood group where two main alleles, Lua and Lub make the current phenotypes Lu(a-b+), Lu (a+b-), and Lu (a+b+). A null phenotype Lu(a-b-) also exists which lacks all Lu antigens, including Lua and Lub (3) It is unknown if it is possible to have antibodies to both Lua and Lub or if a an additional Lutheran antibody that will react with both Lua and Lub will be discovered like in the Kidd blood group.

Note: anti-Lu 3, 4, 5, 6, 8, and 11 have been found (17). Anti-Lu11 does not react with cells that are Lu(a-b-) (16).



Reference:

http://www.jbc.org/content/273/27/16686.full

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1423-0410.1974.tb02388.x

https://books.google.com/books?id=XVTc49cTw3MC&pg=PA283&lpg=PA283&dq=anti-+Lu+11&source=bl&ots=q3DufUxzaE&sig=5YbaJsew5HuHDeFt9_liraNF-x0&hl=en&sa=X&ved=0ahUKEwiF4d-Hsp_aAhWG6lMKHaFmAAYQ6AEIVjAG#v=onepage&q=anti-%20Lu%2011&f=false

http://www.pathology.leedsth.nhs.uk/pathology/ClinicalInfo/AntenatalTesting/AntibodiesinPregnancy.aspx
http://www.redcross.org/images/MEDIA_CustomProductCatalog/m4440096_25_4_09.pdf