Anti-Lea

Blood Group: Lewis

Common: Common

Causes HDN: Yes
Critical Titer: 1:16
Information:
Lewis antibodies are rarely implicated in HDN. For a long time, they were on the list for not causing HDN. However there are both cold and warm reacting versions of these antibodies. The warm reacting IgG type antibodies can cause HDN. Both anti-Leand anti-Leb have been found to cause cases of mild HDN. [1]


Anti-Lea can also result in a positive DAT but require no treatment [3]. This is because anti-Lea can cross the placenta, but there are such low levels of lewis antigens on the blood cells [3].


Articles:

1 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140072/

2 - https://www.ncbi.nlm.nih.gov/pubmed/8484258

3 - https://www.ncbi.nlm.nih.gov/pubmed/3984308

4 - https://www.ncbi.nlm.nih.gov/pubmed/5443062

5 - https://www.ncbi.nlm.nih.gov/pubmed/7198844

6 - https://www.researchgate.net/publication/232625662_The_presence_of_antibodies_in_anti-Lewis_system_in_our_pregnant_women