Anti-Dia

Blood Group: Diego

Common: >99.9% of Caucasians and Blacks and >90% of Asians are Dia- and at risk for developing anti-Dia.

Causes HDN: Yes
Critical Titer: 1:16
Information: 

Anti-Dia can cause moderate to severe HDN [1, 8]. HDN due to Diego antibodies is more common in SE Asia and S. America, though cases have been reported in Japan, China, and Poland. [1] Anti-Dia has been known to cause problems with jaundice requiring exchange transfusion [3, 5, 8]. If not treated promptly, despite single phototherapy, anti-Dia can cause Kernicterus [4].


Anti-Dia has been known to be undetectable on maternal indirect coombs test during pregnancy, yet still cause issues with the infant after birth. [2, 5]. Anti-Dia has also been known to cause late onset anemia, such as in this 3 week old infant [7].


Articles:

1 - https://www.ncbi.nlm.nih.gov/books/NBK2273/
2 - https://www.ncbi.nlm.nih.gov/pubmed/6542344
3 - https://www.ncbi.nlm.nih.gov/pubmed/8942033
4 - https://www.ncbi.nlm.nih.gov/pubmed/18094604
5 - http://onlinelibrary.wiley.com/doi/10.1046/j.1537-2995.1982.22382224952.x/abstract
6 - https://www.ncbi.nlm.nih.gov/pubmed/9774993
7 - https://www.ncbi.nlm.nih.gov/pubmed/12700013
8 - https://www.ncbi.nlm.nih.gov/pubmed/15479965
9 - https://www.ncbi.nlm.nih.gov/pubmed/1519367
10 - https://www.ncbi.nlm.nih.gov/pubmed/2079854
11 - http://www.hkmj.org/system/files/hkm0410p347.pdf
12 - https://www.ncbi.nlm.nih.gov/pubmed/7090038