Anti-C

Blood Group: Rh

Common: 20% of caucasians, 4% of blacks, and 53% of asians are at risk for developing anti-C

Causes HDN: Yes
Critical Titer: 1:16
Information:

Anti-C can cause severe HDN [1]. One of the most important things to note is that with anti-C the direct coombs test done on baby can come back negative, but baby still be severely (or fatally) affected [2]. Because anti-C can require IUTs and cause fetal death, monitoring for anti-C needs to proceed as aggressively as with anti-D [3]. IVIG can be used to treat jaundice due to anti-C [4].


Articles:
1 - https://www.ncbi.nlm.nih.gov/books/NBK2269/
2 - https://www.ncbi.nlm.nih.gov/pubmed/7655573
3 - https://www.ncbi.nlm.nih.gov/pubmed/1566777
4 - http://onlinelibrary.wiley.com/doi/10.1111/j.1651-2227.1991.tb11828.x/abstract